​研究業績

2024年

1. Kato S, Deguchi K, Obana M, Fujio Y, Fukuda Y, Inoue T., Metabolite phosphatase from anhydrobiotic tardigrades. FEBS J. In press. doi: 10.1111/febs.17296.

2. Morihara H, Yamada T, Tona Y, Akasaka M, Okuyama H, Chatani N, Shinonome S, Ueyama A, Kuwabara K, Fujio Y., Anti-CTLA-4 treatment suppresses hepatocellular carcinoma growth through Th1-mediated cell cycle arrest and apoptosis. PLoS One. 2024;19(8):e0305984. doi: 10.1371/journal.pone.0305984

3. Tanaka M., Shirakura K., Takayama Y., Μatsui M., Watanabe Y., Yamamoto T., Takahashi J., Tanaka S., Hino N., Doi T., Obana M., Fujio Y., Takayama K., Okada Y. Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases. Communications Biology. 2024;7(1):599. doi: 10.1038/s42003-024-06317-z

4. Sakai H, Kamuro H, Tokunoh N, Izawa T, Tamiya S, Yamamoto A, Tanaka S, Okuzaki D, Ono C, Matsuura Y, Okada Y, Yoshioka Y, Fujio Y, Obana M. JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice. American Journal of Physiology-Renal Physiology. 2024;326(6):F931-F941. doi: 10.1152/ajprenal.00011.2024

5. Hata K, Nakamura K, Maeda S, Maeda M, Fujio Y, Hirobe S. Infusion-Related Reactions Subsequent to Avelumab, Durvalumab, and Atezolizumab Administration: A Retrospective Observational Study. Clinics and Practice. 2024;14(2):377-387. doi: 10.3390/clinpract14020029.

6. Maeda M, Humber D, Hida E, Ohtani T, Wang G, Wu T, Takeda S, Situ JN, Hayashi J, Nonen S, Takeda T, Okamoto H, Hori M, Sakata Y, Fujio Y, Tsunoda SM. Lower doses of carvedilol in Japanese heart failure patients with reduced ejection fraction could show the potential to be non-inferior to higher doses in US patients: An international collaborative observational study. PLoS One. 2024;19(3):e0299510. doi: 10.1371/journal.pone.0299510. 

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2023年  

1. Suzuki S, Tanaka S, Kametani Y, Umeda A, Nishinaka K, Egawa K, Okada Y, Obana M, Fujio Y. Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes. Physiological Reports. 2023;11(23):e15872. doi: 10.14814/phy2.15872.

2. Tanaka K, Harada H, Kamuro H, Sakai H, Yamamoto A, Tomimatsu M, Ikeda A, Chosokabe R, Tanaka S, Okada Y, Fujio Y, Obana M*. Arid5a/IL-6/PAI-1 signaling is involved in the pathogenesis of lipopolysaccharide-induced kidney injury. Biological and Pharmaceutical Bulletin. 2023; 46: 1753–1760. doi: 10.1248/bpb.b23-00482. Highlighted paper selected by Editor-in-Chief/Featured Article

3. Sakata T, Kohno H, Inui T, Ikeuchi H, Shiko Y, Kawasaki Y, Suzuki S, Tanaka S, Obana M, Ishikawa K, Fujio Y, Matsumiya G. Cardioprotective Effect of Interleukin-11 against Warm Ischemia-Reperfusion Injury in A Rat Heart Donor Model. European Journal of Pharmacology. 2023;961:176145. doi: 10.1016/j.ejphar.2023.176145.

4. Xie Z, Zhou H, Obana M, Fujio Y, Okada N, Tachibana M. Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice. Frontiers in Immunology. 2023;14:1243851. doi: 10.3389/fimmu.2023.1243851.

5. Morita M, Yoneda A, Tokunoh N, Masaki T, Shirakura K, Kinoshita M, Hashimoto R, Shigesada N, Takahashi J, Tachibana M, Tanaka S, Obana M, Hino N, Ikawa M, Tsujikawa K, Ono C, Matsuura Y, Kidoya H, Takakura N, Kubota Y, Doi T, Takayama K, Yoshioka Y, Fujio Y, Okada Y.　Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models. Proceedings of the National Academy of Sciences of the United States of America 2023;120(3):e2213317120. doi: 10.1073/pnas.2213317120.

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2022年

1. Tomimatsu M, Matsumoto K, Ashizuka M, Kumagai S, Tanaka S, Nakae T, Yokota K, Kominami S, Kajiura R, Okuzaki D, Motooka D, Shiraishi A, Abe T, Matsuda H, Okada Y, Maeda M, Seno S, Obana M, Fujio Y. Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling. Scientific Reports. 2022 Oct 5;12(1):16656. doi: 10.1038/s41598-022-21202-7.

2. Hashimoto R, Takahashi J, Shirakura K, Funatsu R, Kosugi K, Deguchi S, Yamamoto M, Tsunoda Y, Morita M, Muraoka K, Tanaka M, Kanbara T, Tanaka S, Tamiya S, Tokunoh N, Kawai A, Ikawa M, Ono C, Tachibana K, Kondoh M, Obana M, Matsuura Y, Ohsumi A, Noda T, Yamamoto T, Yoshioka Y, Torisawa Y, Date H, Fujio Y, Nagao M, Takayama K, Okada Y. SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression, Science Advances. 2022 Sep 23;8(38):eabo6783. doi: 10.1126/sciadv.abo6783.

3. Miyake Y, Obana M, Yamamoto A, Noda S, Tanaka K, Sakai H, Tatsumoto N, Makino C, Kanemoto S, Shioi G, Tanaka S, Maeda M, Okada Y, Imaizumi K, Asanuma K, Fujio Y. Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis. Communications Biology. 2022 Jul 22;5(1):734. doi: 10.1038/s42003-022-03709-x.

4. Noguchi T, Tachibana K, Inoue T, Sakai T, Tsujikawa K, Fujio Y, Yamagishi Y, Hamaguchi S, Kutsuna S, Kondoh M. Safety evaluation of MA-T after ingestion in mice. Toxicology. 2022 Jul;477:153254. doi: 10.1016/j.tox.2022.153254.

5. Obana M, Maeda M, Fujio Y. Glycoprotein 130 orchestrates signal transduction network to promote cardiomyocyte proliferation for normal growth. Am J Physiol Heart Circ Physiol. 2022 Jul 1;323(1):H125-H127. doi: 10.1152/ajpheart.00268.2022.

6. Wahyuni T, Tanaka S, Igarashi R, Miyake Y, Yamamoto A, Mori S, Kametani Y, Tomimatsu M, Suzuki S, Yokota K, Okada Y, Maeda M, Obana M, Fujio Y. CXCL10 is a novel anti-angiogenic factor downstream of p53 in cardiomyocytes. Physiological Reports. 2022 May;10(9):e15304. doi: 10.14814/phy2.15304.

7. Kametani Y, Tanaka S, Wada Y, Suzuki S, Umeda A, Nishinaka K, Okada Y, Maeda M, Miyagawa S, Sawa Y, Obana M, Fujio Y. Yes-associated protein activation potentiates glycogen synthase kinase-3 inhibitor-induced proliferation of neonatal cardiomyocytes and iPS cell-derived cardiomyocytes. Journal of Cellular Physiology. 2022 Mar 21;237:2539-2549. doi: 10.1002/jcp.30724.

8. Akasaka H, Sugimoto K, Shintani A, Taniuchi S, Yamamoto K, Iwakura K, Okamura A, Takiuchi S, Fukuda M, Kamide K, Fujio Y, Nakatani S, Ogihara T, Rakugi H; EXCEED investigators. Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes and heart failure with preserved ejection fraction: The EXCEED randomized controlled multicenter study. Geriatr Gerontol Int. 2022 Apr;22(4):298-304. doi: 10.1111/ggi.14363. 

9. Higashisaka K, Takeya S, Kamada H, Obana M, Maeda M, Kabayama M, Yamamoto K, Ishida N, Isaka R, Tsujino H, Nagano K, Tomiyama N, Rakugi H, Fujio Y, Kamide K, Tsutsumi Y.　Identification of biomarkers of chronic kidney disease among kidney-derived proteins.　Clinical Proteomics. 2022 Jan 11;19(1):3. doi: 10.1186/s12014-021-09340-y.

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2021年

1. Yokoyama H, Shioyama W, Shintani T, Maeda S, Hirobe S, Maeda M, Sakata Y, Fujio Y. Vascular Endothelial Growth Factor Receptor Inhibitors Impair Left Ventricular Diastolic Functions. Int Heart J. 2021;62(6):1297-1304. doi: 10.1536/ihj.21-307.

2. Miyake Y, Obana M, Nakae T, Yamamoto A, Tanaka S, Maeda M, Okada Y, Fujio Y. PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis. Biochemical and Biophysical Research Communications. 2021;571: 88-95. doi: 10.1016/j.bbrc.2021.07.067.

3. Tri Wahyuni, Kobayashi A, Tanaka S, Miyake Y, Yamamoto A, Anton Bahtiar, Mori S, Kametani Y, Tomimatsu M, Matsumoto K, Maeda M, Obana M, Fujio Y. Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway. American Journal of Physiology-Cell Physiology. 2021 Jul 1;321(1):C82-C93. doi: 10.1152/ajpcell.00568.2020.

4. Nakae T, Obana M, Maeda T, Ikeda A, Miyazaki H, Tanaka S, Maeda M, Yamashita K, Terai K, Obika S, Fujio Y. Gene Transfer by Pyro-Drive Jet Injector is a Novel Therapeutic Approach for Muscle Diseases. Gene. 2021 Apr 20;788:145664. doi: 10.1016/j.gene.2021.145664.

5. Shimizu K, Sakurai F, Iizuka S, Ono R, Tsukamoto T, Nishimae F, Nakamura SI, Nishinaka T, Terada T, Fujio Y, Mizuguchi H. Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity. J Immunol. 2021 Jan 15;206(2):410-421. doi: 10.4049/jimmunol.2000830.

6. Yamamoto A, Morioki H, Nakae T, Miyake Y, Harada T, Noda S, Mitsuoka S, Matsumoto K, Tomimatsu M, Kanemoto S, Tanaka S, Maeda M, Conway SJ, Imaizumi K, Fujio Y, Obana M*. Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis. FASEB J. 2021 Feb;35(2):e21158. doi: 10.1096/fj.202001820R.0.

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2020年

1. Tanaka S, Imaeda A, Matsumoto K, Maeda M, Obana M, Fujio Y. β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts. Pharmacol Res Perspect. 2020 Apr;8(2):e00590. doi: 10.1002/prp2.590.

2. Lin Y, Higashisaka K, Shintani T, Maki A, Hanamuro S, Haga Y, Maeda S, Tsujino H, Nagano K, Fujio Y, Tsutsumi Y. Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells. Sci Rep. 2020 Mar 16;10(1):4748. doi: 10.1038/s41598-020-61727-3.

3. Hamatani T, Noda N, Takagaki T, Yodo Y, Kawai H, Kakuyama H, Kaji Y, Fujio Y. Thorough QT/QTc Study Shows That a Novel 5-HT4 Receptor Partial Agonist Minesapride Has No Effect on QT Prolongation. Clin Pharmacol Drug Dev. 2020 Nov;9(8):938-951. doi: 10.1002/cpdd.778.